Chaivation Research

Chaivation: Lion’s Mane, Mucuna, Guarana, Lecithin, Curcumin, Ginger, Piperine, Black pepper, Clove, Cardamon, Coriander

Lions mane mushrooms contains neurogenic/neurotropic, anti-inflammatory, anti-depressant properties, and can modulate monoamine systems such as dopaminergic and serotonergic.1 As an Ayurvedic medicine Mucuna has been used as an aphrodisiac and to treat Parkinson’s disease.2 Mucuna contains neuroprotective properties as well as L-Dopa; necessary for Dopamine production.3 Mucuna contains high amounts of essential amino acids and increase male fertility.4-6 Antidepressant, anxiolytic effects have been observed as well as the decrease in neuroinflammation.7 Guarana contains high amounts of methylxanthines such as caffeine and theobromine giving it stimulating effects. Anti-cancer, anti-obesity, antioxidant, and anti-inflammatory effects have also been observed.8,9 Sunflower lecithin produces a hepatoprotective and anti-diabetic effect as well as reduces risk for cardiovascular disease.10 Sunflower lecithin contains phosphatidylcholine.11Phosphatidylcholine; a source of choline necessary for acetylcholine production vital for brain function and development. 12 Lecithin is supported in the increase in bioavailability of Curcumin.13 Curcumin from turmeric contains antidiabetic, anticarcinogenic, antioxidant and anti-inflammatory properties.14 Other curcuminoids along with curcumin, found in turmeric have been found to have memory enhancing effects15, through their inhibition of acetylcholinesterase(AchE) inhibition, which leads to more acetylcholine; neurotransmitter involved in learning and memory. 16 It also is shown to protect against the toxicity of certain natural and chemical agents.17 Research supports the beneficial effects on ginger on cognition and its use in the prevention of neurodegenerative diseases such as Parkinson’s, Multiple Sclerosis, and Alzheimer’s disease.18-20 Gingers anti-oxidant, anti-cancer, and anti-inflammatory effects have also been supported as well as a preventative measure in nausea and vomiting.21 Piperine from black pepper is also shown to have neuroprotective, anti-inflammatory, anti-diabetic, anti-convulsant, and antiobesity effects.22,23

1. Chong PS, Fung M-L, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. International Journal of Molecular Sciences. 2020;21(1):163.

2. Lampariello L, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G. The magic velvet bean of mucuna pruriens. Article. Journal of Traditional and Complementary Medicine. 2012;2(4):331-339. doi:10.1016/S2225-4110(16)30119-5

3. Natarajan K, Narayanan N, Ravichandran N. Review on "Mucuna" - The wonder plant. Review. International Journal of Pharmaceutical Sciences Review and Research. 2012;17(1):86-93.

4. Yadav MK, Upadhyay P, Purohit S, Pandey BL, Shah H. Phytochemistry and pharmacological activity of Mucuna pruriens: A review. Review. International Journal of Green Pharmacy. 2017;11(2):69-73.

5. Adebowale YA, Adeyemi A, Oshodi AA. Variability in the physicochemical, nutritional and antinutritional attributes of six Mucuna species. Article. Food Chemistry. 2005;89(1):37-48. doi:10.1016/j.foodchem.2004.01.084

6. Shukla KK, Mahdi AA, Ahmad MK, Shankhwar SN, Rajender S, Jaiswar SP. Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis. Fertil Steril. Dec 2009;92(6):1934-40. doi:10.1016/j.fertnstert.2008.09.045

7. Tavares RL, Vasconcelos MHA, Dutra M, et al. Mucuna pruriens Administration Minimizes Neuroinflammation and Shows Anxiolytic, Antidepressant and Slimming Effects in Obese Rats. Molecules. Nov 26 2020;25(23)doi:10.3390/molecules25235559

8. Torres E, Pinaffi-Langley A, Figueira MS, et al. Effects of the consumption of guarana on human health: A narrative review. Compr Rev Food Sci Food Saf. Jan 2022;21(1):272-295. doi:10.1111/1541-4337.12862

9. Marques LL, Panizzon GP, Aguiar BA, et al. Guaraná (Paullinia cupana) seeds: Selective supercritical extraction of phenolic compounds. Food Chem. Dec 1 2016;212:703-11. doi:10.1016/j.foodchem.2016.06.028

10. Butina EA, Gerasimenko EO, Bugaets IA, Dubrovskaia IA. Comparative analysis of the physiological value of lecithins obtained from different types of raw materials. Article. Journal of Pharmaceutical Sciences and Research. 2017;9(12):2493-2497.

11. Lončarević I, Pajin B, Petrović J, et al. The impact of sunflower and rapeseed lecithin on the rheological properties of spreadable cocoa cream. Journal of Food Engineering. 2016/02/01/ 2016;171:67-77. doi:https://doi.org/10.1016/j.jfoodeng.2015.10.001

12. Böckmann KA, Franz AR, Minarski M, et al. Differential metabolism of choline supplements in adult volunteers. Eur J Nutr. Feb 2022;61(1):219-230. doi:10.1007/s00394-021-02637-6

13. Chen LC, Chen YC, Su CY, Wong WP, Sheu MT, Ho HO. Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin. Sci Rep. Nov 16 2016;6:37122. doi:10.1038/srep37122

14. Abd El-Hack ME, El-Saadony MT, Swelum AA, et al. Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability. J Sci Food Agric. Nov 2021;101(14):5747-5762. doi:10.1002/jsfa.11372

15. Ahmed T, Enam SA, Gilani AH. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience. Sep 1 2010;169(3):1296-306. doi:10.1016/j.neuroscience.2010.05.078

16. Ahmed T, Gilani AH. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem Behav. Feb 2009;91(4):554-9. doi:10.1016/j.pbb.2008.09.010

17. Hosseini A, Hosseinzadeh H. Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomed Pharmacother. Mar 2018;99:411-421. doi:10.1016/j.biopha.2018.01.072

18. Arcusa R, Villaño D, Marhuenda J, Cano M, Cerdà B, Zafrilla P. Potential Role of Ginger (Zingiber officinale Roscoe) in the Prevention of Neurodegenerative Diseases. Front Nutr. 2022;9:809621. doi:10.3389/fnut.2022.809621

19. Schepici G, Contestabile V, Valeri A, Mazzon E. Ginger, a Possible Candidate for the Treatment of Dementias? Molecules. Sep 21 2021;26(18)doi:10.3390/molecules26185700

20. Talebi M, İlgün S, Ebrahimi V, et al. Zingiber officinale ameliorates Alzheimer's disease and Cognitive Impairments: Lessons from preclinical studies. Biomed Pharmacother. Jan 2021;133:111088. doi:10.1016/j.biopha.2020.111088

21. Bischoff-Kont I, Fürst R. Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes. Pharmaceuticals (Basel). Jun 15 2021;14(6)doi:10.3390/ph14060571

22. da Cruz GMP, Felipe CFB, Scorza FA, et al. Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms. Pharmacology Biochemistry and Behavior. 2013/03/01/ 2013;104:144-153. doi:https://doi.org/10.1016/j.pbb.2013.01.002

23. Haq I-U, Imran M, Nadeem M, Tufail T, Gondal TA, Mubarak MS. Piperine: A review of its biological effects. https://doi.org/10.1002/ptr.6855. Phytotherapy Research. 2021/02/01 2021;35(2):680-700. doi:https://doi.org/10.1002/ptr.6855

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