CacaoEase: Lion’s mane, Maca, 5htp, B6, L-Theanine, Chamomile, Lecithin.

Lion’s Mane mushroom supports neuroplasticity and healthy brain function by promoting nerve growth factors, which may play a role in mood and cognitive health. .1Lion’s Mane mushroom contains compounds that support the body’s natural antioxidant defenses, immune function, and a healthy inflammatory response.2The natural compounds in maca root support cognitive health, antioxidant activity, energy levels, and healthy reproductive function..3-5Studies in animals suggest that maca may support mood and emotional balance, potentially through its antioxidant activity and influence on neurotransmitter pathways.6L-5-hydroxytryptophan (5-HTP) is a naturally occurring compound synthesized from the amino acid tryptophan and is involved in the body’s production of serotonin and melatonin.7 Vitamin B6 (pyridoxine) plays a key role in tryptophan metabolism and supports the body's natural production of 5-HTP.8 L-Theanine has been studied for its ability to support cognitive function, promote relaxation, and contribute to healthy brain activity.9-12Chamomile extract has been studied for its potential to support relaxation and emotional well-being.13-15Theobromine, a compound found in cacao, has been studied for its role in supporting brain health, cognitive function, and healthy neural signaling.16Antioxidant flavanols found in cacao support cardiovascular health and help protect cells from oxidative stress.17Methylxanthines found in cacao have been studied for their potential role in supporting cognitive health, especially when combined with a healthy, balanced diet.18,19Lipid oxidation is a biological process that has been studied in relation to brain aging and cognitive health.20 Sunflower lecithin supports lipid metabolism and may help protect cells from oxidative stress.21Lecithin is a source of choline, which plays a key role in the production of acetylcholine—a neurotransmitter involved in learning and memory.22,23

1. Chong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. Int J Mol Sci. Dec 25 2019;21(1)doi:10.3390/ijms21010163

2. Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem. Aug 19 2015;63(32):7108-23. doi:10.1021/acs.jafc.5b02914

3. Wang S, Zhu F. Chemical composition and health effects of maca (Lepidium meyenii). Food Chem. Aug 1 2019;288:422-443. doi:10.1016/j.foodchem.2019.02.071

4. Alasmari M, Bӧhlke M, Kelley C, Maher T, Pino-Figueroa A. Inhibition of Fatty Acid Amide Hydrolase (FAAH) by Macamides. Mol Neurobiol. Mar 2019;56(3):1770-1781. doi:10.1007/s12035-018-1115-8

5. Huang YJ, Peng XR, Qiu MH. Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii). Nat Prod Bioprospect. Dec 2018;8(6):405-412. doi:10.1007/s13659-018-0185-7

6. Ai Z, Cheng AF, Yu YT, Yu LJ, Jin W. Antidepressant-like behavioral, anatomical, and biochemical effects of petroleum ether extract from maca (Lepidium meyenii) in mice exposed to chronic unpredictable mild stress. J Med Food. May 2014;17(5):535-42. doi:10.1089/jmf.2013.2950

7. Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. Dec 26 2020;22(1)doi:10.3390/ijms22010181

8. Calderón-Guzmán D, Hernández-Islas JL, Espitia-Vázquez I, et al. Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain. Arch Med Res. Jul-Aug 2004;35(4):271-4. doi:10.1016/j.arcmed.2004.03.003

9. Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30.

10. Kakuda T. Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction. Pharmacol Res. Aug 2011;64(2):162-8. doi:10.1016/j.phrs.2011.03.010

11. Yoneda Y, Kuramoto N, Kawada K. The role of glutamine in neurogenesis promoted by the green tea amino acid theanine in neural progenitor cells for brain health. Neurochem Int. Oct 2019;129:104505. doi:10.1016/j.neuint.2019.104505

12. Yoneda Y. An L-Glutamine Transporter Isoform for Neurogenesis Facilitated by L-Theanine. Neurochem Res. Oct 2017;42(10):2686-2697. doi:10.1007/s11064-017-2317-6

13. Amsterdam JD, Li QS, Xie SX, Mao JJ. Putative Antidepressant Effect of Chamomile (Matricaria chamomilla L.) Oral Extract in Subjects with Comorbid Generalized Anxiety Disorder and Depression. J Altern Complement Med. Sep 2020;26(9):813-819. doi:10.1089/acm.2019.0252

14. Keefe JR, Mao JJ, Soeller I, Li QS, Amsterdam JD. Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder. Phytomedicine. Dec 15 2016;23(14):1699-1705. doi:10.1016/j.phymed.2016.10.013

15. Amsterdam JD, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB. Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. Altern Ther Health Med. Sep-Oct 2012;18(5):44-9.

16. Valada P, Alçada-Morais S, Cunha RA, Lopes JP. Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage. Int J Mol Sci. Sep 10 2022;23(18)doi:10.3390/ijms231810510

17. Garcia JP, Santana A, Baruqui DL, Suraci N. The Cardiovascular effects of chocolate. Rev Cardiovasc Med. Dec 30 2018;19(4):123-127. doi:10.31083/j.rcm.2018.04.3187

18. Janitschke D, Lauer AA, Bachmann CM, et al. Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. Int J Mol Sci. Feb 18 2022;23(4)doi:10.3390/ijms23042295

19. Oñatibia-Astibia A, Franco R, Martínez-Pinilla E. Health benefits of methylxanthines in neurodegenerative diseases. Mol Nutr Food Res. Jun 2017;61(6)doi:10.1002/mnfr.201600670

20. Reed TT. Lipid peroxidation and neurodegenerative disease. Free Radic Biol Med. Oct 1 2011;51(7):1302-19. doi:10.1016/j.freeradbiomed.2011.06.027

21. Mansouri H, Farhoosh R, Rezaie M. Interfacial performance of gallic acid and methyl gallate accompanied by lecithin in inhibiting bulk phase oil peroxidation. Food Chem. Oct 30 2020;328:127128. doi:10.1016/j.foodchem.2020.127128

22. Drugs and Lactation Database (LactMed) Lecithin (National Institute of Child Health and Human Development) (2006).

23. Böckmann KA, Franz AR, Minarski M, et al. Differential metabolism of choline supplements in adult volunteers. Eur J Nutr. Feb 2022;61(1):219-230. doi:10.1007/s00394-021-02637-6