Calmfidence:A Calm State of Confidence

Ingredients: Propietary Blend: Agmatine, L Theanine, Magnesium, Piperine, Glycine, B-1, B-6, B-12

Agmatine decarboxylized from the amino acid arginine and found in soybean and Manaca plants enhances Nitric oxide production, as well as increases dopamine production through increasing the enzyme tyrosinase necessary for the conversion of tyrosine to L-Dopa which then converts into dopamine.1 Modulating some processes of learning and memory,2 evidence supports the use of agmatine in the treatment a variety of diseases including, opioid addiction, cancer, cognitive disorders, diabetes millitus, mood disorders, neurodegenerative diseases and neurotrauma.3 An amino acid found in green tea L-Theanine reduces the stress response by preventing cortical neuron excitation via glutamate receptors.4Combining L-Theanine with magnesium enhances this effect, increases GABA, dopamine, serotonin, and melatonin. It also is shown to regulate brain electrical activity by increasing slow-brain waves, enhancing quality of sleep.5Magnesium is essential for a for the proper functioning of many biochemical and metabolic processes throughout the body. Its deficiency has been indicated in the body’s vulnerability to stress. Stress is also indicated in as a cause of magnesium deficiency.6 Piperine is shown to increase striatal levels of glycine and GABA.7 It also has anti-depressant, analgesic,8 neuroprotective and anti-inflammatory properties.9 Neurological function and sleep quality enhancement are properties of glycine.10 The combination of glycine with N-acetylcysteine improved muscle strength, exercise capacity, and cognition11 Increased oxidative stress and impaired energy metabolism is found in Thiamine(B-1) deficiency. Diseases such as Alzheimers, Parkinsons, and diabetes may benefit from B-1 supplementation.12 Necessary for almost 200 central nervous system biochemical reactions, B6 13Necessary for central nervous system function through myelination and normal bone marrow, B12 is also involved in DNA synthesis.14,15

1. Kwon EJ, Kim MM. Agmatine modulates melanogenesis via MITF signaling pathway. Environ Toxicol Pharmacol. Jan 2017;49:124-130. doi:10.1016/j.etap.2016.12.008

2. Uzbay T. A new target for diagnosis and treatment of CNS disorders: agmatinergic system. Curr Med Chem. 2012;19(30):5116-21. doi:10.2174/092986712803530601

3. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today. Sep 2013;18(17-18):880-93. doi:10.1016/j.drudis.2013.05.017

4. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. Jan 2007;74(1):39-45. doi:10.1016/j.biopsycho.2006.06.006

5. Dasdelen MF, Er S, Kaplan B, et al. A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality via Regulating Brain Electrochemical Activity. Front Nutr. 2022;9:874254. doi:10.3389/fnut.2022.874254

6. Pickering G, Mazur A, Trousselard M, et al. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. Nov 28 2020;12(12)doi:10.3390/nu12123672

7. Cruz GMPd, Felipe CFB, Scorza FA, et al. Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms. Pharmacology, Biochemistry and Behavior. Mar 2013

2020-10-22 2013;104:144-153. doi:https://doi.org/10.1016/j.pbb.2013.01.002

8. Imran M, Samal M, Qadir A, Ali A, Mir SR. A critical review on the extraction and pharmacotherapeutic activity of piperine. Polim Med. Jan-Jun 2022;52(1):29-34. doi:10.17219/pim/145512

9. Haq IU, Imran M, Nadeem M, Tufail T, Gondal TA, Mubarak MS. Piperine: A review of its biological effects. Phytother Res. Feb 2021;35(2):680-700. doi:10.1002/ptr.6855

10. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701. doi:10.1155/2017/1716701

11. Sekhar RV. GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging. J Nutr. Dec 3 2021;151(12):3606-3616. doi:10.1093/jn/nxab309

12. Frank LL. Thiamin in Clinical Practice. JPEN J Parenter Enteral Nutr. Jul 2015;39(5):503-20. doi:10.1177/0148607114565245

13. Guerriero RM, Patel AA, Walsh B, et al. Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. Pediatr Neurol. Nov 2017;76:47-53. doi:10.1016/j.pediatrneurol.2017.05.024

14. Silverstein WK, Cheung MC, Lin Y. Vitamin B(12) deficiency. Cmaj. Jun 20 2022;194(24):E843. doi:10.1503/cmaj.220306

15. Stabler S. Vitamin B 12 Deficiency. New England Journal of Medicine (NEJM). 2013;368(2):149-160. doi:10.1056/NEJMcp1113996

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